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Theral Timpson

Can Liquid Biopsy Transform Chronic Disease? Hamed Amini and Soheil Damangir of Hepta

June 25, 2026 11:33am 4 min

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor the past decade, liquid biopsy has largely been defined by oncology. Tumors shed DNA carrying mutations and epigenetic changes which all...

The UAE’s Big Bet on Genomic Medicine with Mohamed Alameri and Albarah El-Khani

June 23, 2026 10:46am 46 min

The future of genomics has arrived in Abu Dhabi.On today’s show, Dr. Mohamed Alameri of the UAE Department of Health and Albarah El-Khani of M42 describe one of the most ambitious precision medicine efforts underway anyw...

Ryan Flynn of Harvard on Non-Coding RNA

June 18, 2026 10:25am 41 min

On today’s show, Dr. Ryan Flynn of Harvard Medical School and Boston Children’s Hospital takes us into a newly emerging layer of biology: the architecture of the cell surface itself. Flynn first gained attention for the ...

Gary Schroth on Connecting Cellular Behavior to the Transcriptome

June 11, 2026 10:25am 32 min

For decades, biology has been driven by the powerful notion that if we could sequence enough genomes, transcriptomes, epigenomes, then we could finally explain the cell. On today’s show, Gary Schroth, the Chief Scientifi...

Two-Thirds of High-Risk Breast Cancer Patients May Avoid Chemotherapy According to Veracyte Data Presented at ASCO

June 09, 2026 10:13am 27 min

Today on the show, we’re discussing a new study just presented at ASCO 2026 that could change how chemotherapy decisions are made for a large group of breast cancer patients.During ASCO we spoke with Phil Febbo, Chief Sc...

Building the Diagnostic Layer of Modern Cancer Care with Rita Shaknovich and Karina Kulangara of Agilent

May 29, 2026 11:01am 31 min

For years, precision oncology has largely been discussed through the lens of breakthrough drugs. But there’s another story running underneath modern cancer care: the quiet rise of companion diagnostics. These tests are ...

Mapping the Multi-Omic Era with Eric Green of Illumina

May 28, 2026 9:56am 44 min

Dr. Eric Green returns to Mendelspod in a new role: Chief Medical Officer of Illumina. After more than three decades at the National Human Genome Research Institute, where he helped guide genomics from research initiativ...

Inside Proteomics at Thermo Fisher with Yan Zhang

May 21, 2026 10:45am 4 min

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor years, proteomics was described as the missing layer of biology. Why missing? Because measuring proteins at scale turned out to be vast...

Separating Epigenetic Signals Improves Early Cancer Detection with Rob Osborne, Biomodal

May 19, 2026 10:12am 23 min

We’ve gotten very good at reading DNA. We’re just beginning to understand how to read its state.On today’s show, Rob Osborne, Senior Vice President of R&D at Biomodal, discusses new evidence that separating two epigeneti...

Digital Controls for Cancer Drug Trials? Irina Babina, Concr

May 15, 2026 9:55am 4 min

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOn today’s show, a fascinating discussion about digital twins for medical research— leading to the 64 million dollar question of how much of...

Solexa Co-Inventor Shankar Balasubramanian on Six-Base Sequencing and What's Next in Genomics

May 07, 2026 11:09am 37 min

An inventor of Solexa sequencing by synthesis has a new idea.On today’s show, Sir Shankar Balasubramanian revisits the accidental origins of Solexa sequencing, born not from a sequencing project at all, but from curiosit...

The Next Frontier in Biology: Physics? Erdinc Sezgin of the Karolinska Institute

April 30, 2026 8:49am 32 min

There’s a famous line attributed to Ernest Rutherford, the father of nuclear physics: “All science is either physics or stamp collecting.” It’s still provocative. But it’s unfair to biology. Long before today’s omics e...

The Case for a 6-Base Genome with Peter Fromen, CEO of Biomodal

April 28, 2026 9:52am 35 min

You’ve heard of 5-base genomics. How about 6-base? It turns out that separating 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) is pretty important.Peter Fromen has had a front-row seat to the evolution of sequen...

The Eligible But Under-Tested: Genomic Medicine in 2026 with Damon Hostin, Illumina

April 14, 2026 9:08am 39 min

What is the value of someone’s genome over their life? Is a genome today what it was 10 years ago? How does the adoption of genomic testing compare to other areas in medicine, such as imaging or electronic health recor...

Spatial Transcriptomics Is Changing How We Do Biology: Fei Chen, The Broad Institute

April 09, 2026 3:27pm 31 min

Fei Chen of the Broad Institute describes the original problem simply: genomics gave us powerful inventories of gene expression, while microscopy gave us structure—yet the two lived in separate worlds. “You could either ...

Beyond GLP-1: Why Peptides Are Back at the Center of Drug Discovery with Charlie Johannes and Tomi Sawyer

April 07, 2026 10:46am 44 min

Peptides are having a moment. But beneath the market excitement and the GLP-1 headlines, something more interesting is going on. A field that for years seemed technically promising but perpetually constrained is becoming...

From the Archives: Inventor Mark Kokoris Debuts Roche’s New SBX Sequencer

April 02, 2026 11:37am 35 min

It was the biggest story in sequencing last year: Mark Kokoris, head of SBX sequencing at Roche and inventor of the technology, joins Mendelspod to talk about how Sequencing by Expansion (SBX) works and why it may redefi...

Why Do Some Animals Live Ten Times Longer? Pursuing the Science of Aging with Steve Austad

March 17, 2026 10:33am 38 min

Why do some animals live ten times longer than others?That question opens today’s interview with Steve Austad, Distinguished Professor at the University of Alabama at Birmingham and one of the leading thinkers in the bio...

MRD Testing: From Residual Disease to Real Decisions with Chris Hourigan and Gary Pestano

March 10, 2026 9:53am 33 min

Molecular residual disease, or MRD, has been part of oncology’s vocabulary for decades. But knowing something is there and being able to measure it precisely are two very different things. In today’s show, we explore h...

Early vs Late Recurrence: How Multimodal AI Is Changing Breast Cancer Prognosis with George Sledge, Caris Life Sciences

March 05, 2026 10:02am 4 min

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor two decades, tests like Oncotype DX have helped oncologists decide which early-stage breast cancer patients should receive chemotherapy....

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